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{"id":6920,"date":"2015-12-22T10:55:33","date_gmt":"2015-12-22T08:55:33","guid":{"rendered":"https:\/\/www.coolkadin.com\/?p=6920"},"modified":"2015-12-22T10:55:33","modified_gmt":"2015-12-22T08:55:33","slug":"cgh-komperatif-genomik-hibridizasyon","status":"publish","type":"post","link":"https:\/\/www.coolkadin.com\/cgh-komperatif-genomik-hibridizasyon.html","title":{"rendered":"CGH (Komperatif Genomik Hibridizasyon)"},"content":{"rendered":"

Normal sa\u011fl\u0131kl\u0131 yumurtalar\u0131n se\u00e7ilip dondurulmas\u0131 i\u015flemidir. Kromozom bilindi\u011fi gibi yap\u0131 ta\u015f\u0131m\u0131zd\u0131r. Kromozom yap\u0131s\u0131 sa\u011fl\u0131kl\u0131 de\u011filse gebelik olu\u015fmaz, gebe kal\u0131nsa dahi d\u00fc\u015f\u00fckle sonlan\u0131r. (Bu nedenle sa\u011fl\u0131kl\u0131 embriyolar\u0131n\u0131n tespiti \u00e7ok \u00f6nemlidir.) Nesiller aras\u0131ndaki genetik \u00f6zellikler anne babadan \u00e7ocu\u011fa kromozomlar ile ge\u00e7er. Kromozomlar insanda 46 adettir ve kendinden \u00f6nceki atalar\u0131n\u0131n b\u00fct\u00fcn \u00f6zelliklerine sahiptir.<\/p>\n

D\u00fcnya da say\u0131l\u0131 merkezlerde yap\u0131lan ve ba\u015far\u0131s\u0131z t\u00fcp bebeklerin yeni umudu CGH y\u00f6ntemi ile art\u0131k T\u00fcrkiye\u2019de de uygulanmaya ba\u015fland\u0131. Genellikle yap\u0131lan ve PGD(preimplantasyon genetik tan\u0131)diye bilinen y\u00f6ntemle ancak belli kromozomlar incelenebiliyor ve onlardaki bozukluklar tespit edilebiliyordu. H\u00e2lbuki yeni y\u00f6ntemle b\u00fct\u00fcn kromozomlar tetkik edilebiliyor, gebeli\u011fi engelleyen veya gebelikle olu\u015fabilecek genetik problemler saptanabiliyor. En kaliteli ve yap\u0131sal olarak en sa\u011flam embriyolar kullan\u0131ld\u0131\u011f\u0131 i\u00e7in %45-%55olan tek embriyo transfer ba\u015far\u0131 oran\u0131 %70-75 oran\u0131na kadar \u00e7\u0131kabilmektedir ki bu \u015fimdiye kadar ula\u015f\u0131lamam\u0131\u015f bir ba\u015far\u0131 oran\u0131d\u0131r.<\/p>\n

K\u0130MLERE TAVS\u0130YE ED\u0130YORUZ<\/p>\n

-38 Ya\u015f ve \u00fczeri anne adaylar\u0131<\/p>\n

-Ya\u015fa hi\u00e7 bakmadan 2 kez t\u00fcp bebek tedavisi uygulan\u0131p gebelik olu\u015fmad\u0131ysa,<\/p>\n

-Daha \u00f6nce PGD yap\u0131lm\u0131\u015f ve 1 normal embriyo tespit edilip transfer sonucu negatif ise,<\/p>\n

-Tekrarlayan d\u00fc\u015f\u00fckleri olup anatomik bir sebep bulunmad\u0131ysa,<\/p>\n

-Azoospermi(s\u0131f\u0131r sperm)ve 5 milyona kadar spermi olan erkeklerde CGH i\u00e7in plan yap\u0131labilir.<\/p>\n

HCG uygulamas\u0131n\u0131n bir di\u011fer avantaj\u0131, elde edilen embriyolar\u0131n hepsinin t\u00fcm kromozomlar\u0131n\u0131n incelenmesi sonucu en kaliteli ve genetik a\u00e7\u0131dan en sa\u011flam\u0131 tespit edilerek 1 embriyo transfer ediliyor ve hem y\u00fcksek gebelik oran\u0131 elde ediliyor ve hem de \u00e7o\u011ful gebelik olma ihtimali ortadan kalk\u0131yor. Buda anne ve \u00e7ocuk sa\u011fl\u0131\u011f\u0131 i\u00e7in avantaj sa\u011fl\u0131yor.<\/p>\n

CGH \u0130\u015eLEM\u0130NDE NE YAPILIYOR?<\/p>\n

T\u00fcp bebek tedavisi i\u00e7in gelen anne adaylar\u0131n\u0131n yumurtalar\u0131 uygulanan yumurta uyar\u0131lma tedavisi sonras\u0131 toplan\u0131yor. E\u015finin spermi ile laboratuar ortam\u0131nda \u00f6zel mikroskop ve mikro man\u00fcplat\u00f6r e\u015fli\u011finde d\u00f6llenir. D\u00f6llenen embriyolardan, geli\u015fiminin 3. g\u00fcn\u00fcnde 6-8 h\u00fccreli olduktan sonra lazer e\u015fli\u011finde 1 h\u00fccre veya 5.g\u00fcn\u00fcnde embriyodan e\u015finin( placenta)geli\u015fece\u011fi k\u0131s\u0131mdan (Trofektoderm)lazerle al\u0131nan 3-5 h\u00fccre al\u0131n\u0131r. Tecr\u00fcbeli embriyolog ve geli\u015fmi\u015f aletlerle yap\u0131lan bu i\u015flemin embriyoya hi\u00e7bir zarar\u0131 yoktur. Kalan h\u00fccreler b\u00f6l\u00fcn\u00fcp geli\u015fimine devam eder, sadece al\u0131nan h\u00fccre incelemeye al\u0131n\u0131r ve bu h\u00fccre mikroarray tabanl\u0131 kar\u015f\u0131la\u015ft\u0131rmal\u0131 genomik hibridizasyon CGH yap\u0131l\u0131r. \u0130ncelemenin do\u011frulu\u011funun %95’e kadar \u00e7\u0131kt\u0131\u011f\u0131 d\u00fc\u015f\u00fcn\u00fcl\u00fcrse, kaliteli gebelik \u015fans\u0131n\u0131n da ne kadar artabilece\u011fi daha iyi anla\u015f\u0131lmaktad\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"

Normal…<\/p>\n","protected":false},"author":1,"featured_media":6924,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1523],"tags":[587,1373,225,471,4114,1461,3930],"_links":{"self":[{"href":"https:\/\/www.coolkadin.com\/wp-json\/wp\/v2\/posts\/6920"}],"collection":[{"href":"https:\/\/www.coolkadin.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.coolkadin.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.coolkadin.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.coolkadin.com\/wp-json\/wp\/v2\/comments?post=6920"}],"version-history":[{"count":0,"href":"https:\/\/www.coolkadin.com\/wp-json\/wp\/v2\/posts\/6920\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.coolkadin.com\/wp-json\/wp\/v2\/media\/6924"}],"wp:attachment":[{"href":"https:\/\/www.coolkadin.com\/wp-json\/wp\/v2\/media?parent=6920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.coolkadin.com\/wp-json\/wp\/v2\/categories?post=6920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.coolkadin.com\/wp-json\/wp\/v2\/tags?post=6920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}